Research Division of Genome Companion Diagnostics,
Hokkaido University Hospital
ゲノム・コンパニオン診断研究部門の研究成果 - 研究成果の報告
学術誌での成果報告
Hagio K, Hatanaka KC, Amano T, Matsuno Y, Hatanaka Y, Yamashita H. Genetic heterogeneity during breast cancer progression in young patients. Breast. 2021; 60: 206-213.
Hirai N, Hatanaka Y, Hatanaka KC, Uno Y, Chiba SI, Umekage Y, Minami Y, Okumura S, Ohsaki Y, Sasaki T. Cyclin-dependent kinase 4 upregulation mediates acquired resistance of dabrafenib plus trametinib in BRAF V600E-mutated lung cancer. Transl Lung Cancer Res. 2021; 10(9): 3737-3744.
Hatanaka Y, Kuwata T, Morii E, Kanai Y, Ichikawa H, Kubo T, Hatanaka KC, Sakai K, Nishio K, Fujii S, Okamoto W, Yoshino T, Ochiai A, Oda Y. The Japanese Society of Pathology Practical Guidelines on the handling of pathological tissue samples for cancer genomic medicine. Pathol Int. 2021. Online ahead of print.
Matsui H, Homma S, Hatanaka KC, Sawada A, Imaizumi K, Yoshida T, Ichikawa N, Emoto S, Miyaoka Y, Takahashi N, Matsuno Y, Hatanaka Y, Taketomi A. Novel Prognostic Stratification Factor Based on the Pathological Profile of the Invasive Front in Colorectal Cancer. Anticancer Res. 2021;41(7): 3429-3438.
Morimoto H, Hida Y, Maishi N, Nishihara H, Hatanaka Y, Li C, Matsuno Y, Nakamura T, Hirano S, Hida K. Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer. Thoracic Cancer. 2021; 12(9): 1347-1357.
Kikuchi J, Ohhara Y, Takada K, Tanabe H, Hatanaka K, Amano T, C Hatanaka K, Hatanaka Y, Mitamura T, Kato M, Shibata Y, Yabe I, Endoh A, Komatsu Y, Matsuno Y, Sugiyama M, Manabe A, Sakurai A, Takahashi M, Naruse H, Torimoto Y, Dosaka-Akita H, Kinoshita I. Clinical significance of comprehensive genomic profiling tests covered by public insurance in patients with advanced solid cancers in Hokkaido, Japan. Jpn J Clin Oncol. 2021; 51(5): 753-761.
Kato T, Ujiie H, Hatanaka KC, Nange A, Okumura A, Tsubame K, Naruchi K, Sato M, Kaga K, Matsuno Y, Wakasa S, Hatanaka Y. A novel Tn antigen epitope-recognizing antibody for MUC1 predicts clinical outcome in patients with primary lung adenocarcinoma. Oncol Lett. 2021; 21(3): 202.
Matsuzawa F, Kamachi H, Mizukami T, Einama T, Kawamata F, Fujii Y, Fukai M, Kobayashi N, Hatanaka Y, Taketomi A. Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells. BMC Cancer. 2021; 21: 200.
Suzuki T, Kano S, Suzuki M, Yasukawa S, Mizumachi T, Tsushima N, Hatanaka KC, Hatanaka Y, Matsuno Y, Homma A. Enhanced Angiogenesis in Salivary Duct Carcinoma Ex-Pleomorphic Adenoma. Front Oncol. 2021; 10: 603717.
Ito S, Asahina H, Yamaguchi N, Tomaru U, Hasegawa T, Hatanaka Y, Hatanaka KC, Taguchi H, Harada T, Ohira H, Ikeda D, Mizugaki H, Kikuchi E, Kikuchi J,Sakakibara-Konishi J, Shinagawa N, Konno S. A case of radio-insensitive SMARCA4-deficient thoracic undifferentiated carcinoma with severe right heart failure. Respir Med Case Rep. 2021; 32: 101364.
Ebata N, Fujita M, Sasagawa S, Maejima K, Okawa Y, Hatanaka Y, Mitsuhashi T, Oosawa-Tatsuguchi A, Tanaka H, Miyano S, Nakamura T, Hirano S, Nakagawa H. Molecular Classification and Tumor Microenvironment Characterization of Gallbladder Cancer by Comprehensive Genomic and Transcriptomic Analysis. Cancers (Basel). 2021; 13(4): 733.
Kuwata T, Wakabayashi M, Hatanaka Y, Morii E, Oda Y, Taguchi K, Noguchi M, Ishikawa Y, Nakajima T, Sekine S, Nomura S, Okamoto W, Fujii S, Yoshino T; SCRUM-Japan GI-SCREEN Pathology Group. Impact of DNA integrity on the success rate of tissue-based next-generation sequencing: Lessons from nationwide cancer genome screening project SCRUM-Japan GI-SCREEN. Pathol Int. 2020; 70(12): 932-942.
Yatabe Y, Sunami K, Goto K, Nishio K, Aragane N, Ikeda S, Inoue A, Kinoshita I, Kimura H, Sakamoto T, Satouchi M, Shimizu J, Tsuta K, Toyooka S, Nishino N, Hatanaka Y, Matsumoto S, Mikubo M, Yokose T, Dosaka-Akita H. Multiplex Gene-panel Testing for Lung Cancer Patients. Pathol Int. 2020; 70(12): 921-931.
Fujimoto K, Hatanaka KC, Hatanaka Y, Kasahara I, Yamamoto S, Tsuji T, Nakata M, Takakuwa Y, Haseyama Y, Oyamada Y, Yonezumi M, Suzuki H, Sakai H, Noguchi H, Mori A, Nishihara H, Teshima T, Matsuno Y. Association of Epstein-Barr virus with regression after withdrawal of immunosuppressive drugs and subsequent progression of iatrogenic immunodeficiency-associated lymphoproliferative disorders in patients with autoimmune diseases. Hematol Oncol. 2020; 38(5): 799-807.
Ebi H, Bando H, Taniguchi H, Sunakawa Y, Okugawa Y, Hatanaka Y, Hosoda W, Kumamoto K, Nakatani K, Yamazaki K. Japanese Society of Medical Oncology (JSMO) Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, 4th Edition. Cancer Sci. 2020; 111(10): 3962-3969.
Hane Y, Tsuchikawa T, Nakamura T, Hatanaka KC, Saito T, Tanaka K, Nakanishi Y, Asano T, Noji T, Okamura K, Shichinohe T, Yokota I, Hatanaka Y, Hirano S. Immunological gene signature associated with the tumor microenvironment of pancreatic cancer after neoadjuvant chemotherapy. Pancreas. 2020; 49(9): 1240-1245.
Fujiwara K, Sasawatari S, Nakai S, Imaeda K, Nagai S, Matsuno Y, Hatanaka K, Hatanaka Y, Takenaka S, Okada N. Predicting the efficacy and safety of TACTICs (Tumor Angiogenesis-Specific CAR-T Cells Impacting Cancers) therapy for soft tissue sarcoma patients. Cancers (Basel). 2020; 12(10): 2735.
Aiyama T, Orimo T, Yokoo H, Ohata T, Hatanaka KC, Hatanaka Y, Fukai M, Kamiyama T, Taketomi A. Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis. PLoS One. 2020; 15(9): e0239462.
Asahi Y, Hatanaka KC, Hatanaka Y, Kamiyama T, Orimo T, Shimada S, Nagatsu A, Sakamoto Y, Kamachi H, Kobayashi N, Fukai M, Taketomi A. Prognostic impact of CD8+ T cell distribution and its association with the HLA class I expression in intrahepatic cholangiocarcinoma. Surg Today. 2020; 50(8): 931-940.
Asano H, Hatanaka KC, Matsuoka R, Dong P, Mitamura T, Konno Y, Kato T,Kobayashi N, Ihira K, Nozaki A, Oku A, Matsuno Y, Hatanaka Y, Watari H. L1CAM predicts adverse outcomes in patients with endometrial cancer undergoing full lymphadenectomy and adjuvant chemotherapy. Ann Surg Oncol. 2020; 27(7): 2159-2168.
Naito Y, Mishima S, Akagi K, Igarashi A, Ikeda M, Okano S, Kato S, Takano T, Tsuchihara K, Terashima K, Nishihara H, Nishiyama H, Hiyama E, Hirasawa A, Hosoi H, Maeda O, Yatabe Y, Okamoto W, Ono S, Kajiyama H, Nagashima F, Hatanaka Y, Miyachi M, Kodera Y, Yoshino T, Taniguchi H. Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult andpediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology. Int J Clin Oncol. 2020; 25(3): 403-417.
Yamashita H, Ishida N, Hatanaka Y, Hagio K, Oshino T, Takeshita T, Kanno-Okada H, Shimizu AI, Hatanaka KC, Matsuno Y. HER2 Gene Amplification in ER-positive HER2 Immunohistochemistry 0 or 1+ Breast Cancer With Early Recurrence. Anticancer Res. 2020; 40(2): 645-652.
Yamamoto K, Ohnishi S, Mizushima T, Kodaira J, Ono M, Hatanaka Y, Hatanaka KC, Kuriki Y, Kamiya M, Ehira N, Shinada K, Takahashi H, Shimizu Y, Urano Y, Sakamoto N. Detection of early adenocarcinoma of the esophagogastric junction byspraying an enzyme-activatable fluorescent probe targeting Dipeptidyl peptidase-IV. BMC Cancer. 2020; 20(1): 64.
Sakakibara-Konishi J, Kitai H, Ikezawa Y, Hatanaka Y, Sasaki T, Yoshida R, Chiba S, Matsumoto S, Goto K, Mizugaki H, Shinagawa N. Response to crizotinib re-administration after progression on lorlatinib in a patient with ALK-rearranged non-small cell lung cancer. Clin Lung Cancer. 2019; 20(5): e555-e559.
Kuwabara S, Tsuchikawa T, Nakamura, T, Hatanaka Y, Hatanaka K, Sasaki K, Ono M, Umemoto K, Suzuki T, Sato O, Hane Y, Nakanishi Y, Asano T, Ebihara, Y, Kurashima Y, Noji T, Murakami S, Okamura K, Shichinohe T, Hirano S. Prognostic Relevance of Tertiary Lymphoid Organs Following Neoadjuvant Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma. Cancer Sci. 2019; 110(6): 1853-1862.
Hatanaka KC, Takakuwa E, Hatanaka Y, Suzuki A, Iizuka S, Tsushima N, Mitsuhashi T, Sugita S, Homma A, Morinaga S, Hashegawa T, Matsuno Y. Desmoplastic small round cell tumor of the parotid gland-Report of a rare case and a review of the literature. Diagn Pathol. 2019; 14(1): 43.
Ogino M, Nakanishi Y, Mitsuhashi T, Hatanaka Y, Amano T, Marukawa K, Nitta T, Ueno T, Ono M, Kuwabara S, Yamada T, Hirano S. Impact of tumour budding grade in 310 patients who underwent surgical resection for extrahepatic cholangiocarcinoma. Histopathology. 2019; 74(6): 861-872.
Masuda S, Nonokawa M, Futamata E, Nishibata Y, Iwasaki S, Tsuji T, Hatanaka Y, Nakazawa D, Tanaka S, Tomaru U, Kawakami T, Atsumi T, Ishizu A. Formation and Disordered Degradation of Neutrophil Extracellular Traps in Necrotizing Lesions of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Am J Pathol. 2019; 189(4): 839-846.
Mizukami T, Kamachi H, Mitsuhashi T, Einama T, Hatanaka Y, Kamiyama T, Taketomi A. Cytoplasmic CD133 expression correlates with histologic differentiation and is a significant prognostic factor in extrahepatic bile duct cancer and gallbladder cancer. Oncol Lett. 2018; 16(5): 6423-6430.
Kato T, Jin CS, Lee D, Ujiie H, Fujino K, Hu HP, Wada H, Wu L, Chen J, Weersink RA, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Wilson BC, Zheng G, Yasufuku K. Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma. Int J Oncol. 2018; 53(5): 2034-2046.
Mizukami T, Kamachi H, Fujii Y, Matsuzawa F, Einama T, Kawamata F, Kobayashi N, Hatanaka Y, Taketomi A. The anti-mesothelin monoclonal antibody amatuximab enhances the anti-tumor effect of gemcitabine against mesothelin-high expressing pancreatic cancer cells in a peritoneal metastasis mouse model. Oncotarget. 2018; 9(73): 33844-33852.
Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Kuriki Y, Kamiya M, Homma A, Yamamoto K, Ono S, Urano Y, Sakamoto N. Rapid detection of superficial head and neck squamous cell carcinoma by topically spraying fluorescent probe targeting dipeptidyl peptidase-IV. Head Neck. 2018; 40(7): 1466-1475.
Takashima Y, Sakakibara-Konishi J, Hatanaka Y, Hatanaka KC, Ohhara Y, Oizumi S, Hida Y, Kaga K, Kinoshita I, Dosaka-Akita H, Matsuno Y, Nishimura M. Clinicopathologic Features and Immune Microenvironment of Non-Small-cell Lung Cancer With Primary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. Clin Lung Cancer. 2018; 19(4): 352-359.
Tabata Y, Nakanishi Y, Hatanaka KC, Hatanaka Y, Tsuchikawa T, Okamura K, Noji T, Shichinohe T, Matsuno Y, Hirano S. DJ-1 is a useful biomarker for invasive extrahepatic cholangiocarcinoma. Hum Pathol. 2018; 76: 28-36.
Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M1, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki K, Kawakami Y, Aikata H, Ueno M, Hayami S, Gotoh K, Ariizumi SI, Yamamoto M, Yamaue H, Chayama K, Miyano S, Getz G, Scarpa A, Hirano S, Nakamura T, Nakagawa H. Genomic Characterization of Biliary Tract Cancers Identifies Driver Genes and Predisposing Mutations. J Hepatol. 2018; 68(5): 959-969.
Ueno T, Tsuchikawa T, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakanishi Y, Noji T, Nakamura T, Okamura K, Matsuno Y, Hirano S. Prognostic impact of programmed cell death ligand 1 (PD-L1) expression and its association with epithelial-mesenchymal transition in extrahepatic cholangiocarcinoma. Oncotarget. 2018; 9(28): 20034-20047.
Ishida N, Baba M, Hatanaka Y, Hagio K, Okada H, Hatanaka KC, Togashi K, Matsuno Y, Yamashita H. PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive early breast cancer. Oncotarget. 2018; 9(25): 17711-17724.
Sugita S, Hirano H, Hatanaka Y, Fujita H, Kubo T, Kikuchi N, Ito Y, Sugawara T, Segawa K, Hisai H, Yamashita K, Nobuoka T, Matsuno Y, Hasegawa T. Image analysis is an excellent tool for quantifying Ki-67 to predict the prognosis of gastrointestinal stromal tumor patients. Pathol Int. 2018; 68(1): 7-11.
Nakatani M, Watari H, Mitamura T, Wang L, Hatanaka Y, Hatanaka KC, Honda K, Nomura T, Nishihara H, Tanaka S, Sakuragi N. The anti-tumor effect of cabozantinib on ovarian clear cell carcinoma in vitro and in vivo. Anticancer Res. 2017; 37(11): 6125-6132.
Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S. Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors. Oncotarget. 2017; 8(63): 106206-106221.
Kanno-Okada H, Takakuwa E, Tagawa Y, Kase S, Hatanaka KC, Hatanaka Y, Namba K, Mitsuhashi T, Matsuno Y. Cytopathologic findings of cell block materials from the vitreous: Diagnostic distinction between intraocular lymphoma and non-lymphomatous diseases. Pathol Int. 2017; 67(7): 342-349.
Ohata T, Yokoo H, Kamiyama T, Fukai M, Aiyama T, Hatanaka Y, Hatanaka K, Wakayama K, Orimo T, Kakisaka T, Matsuno Y, Taketomi A. Fatty acid binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition. Cancer Medicine. 2017; 6(5): 1049-1061.
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu HP, Ujiie H, Kaji M, Kano S, Matsuge S, Domen H, Kanno H, Hatanaka Y, Hatanaka KC, Kaga K, Matsui Y, Matsuno Y, De Perrot M, Yasufuku K. SORORIN and PLK1 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 2016; 49(6): 2411-2420.
Otsuka Y, Sato H, Oikawa T, Onodera Y, Nam JM, Hashimoto A, Fukunaga K, Hatanaka KC, Hatanaka Y, Matsuno Y, Fukuda S, Sabe H. High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue. Cell Commun Signal. 2016; 14(1): 28.
Kato T, Lee D, Wu L, Patel P, Young AJ, Wada H, Hu HP, Ujiie H, Kaji M, Kano S, Matsuge S, Domen H, Kaga K, Matsui Y, Kanno H, Hatanaka Y, Hatanaka KC, Matsuno Y, de Perrot M, Yasufuku K. Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma. Int J Oncol. 2016; 49(2): 448-456.
Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Hosono H, Kubota Y, Natsuizaka M, Kamiya M, Ono S, Homma A, Kato M, Sakamoto N, Urano Y. Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated targeting agent: a pilot study. BMC Cancer. 2016; 16: 411.
Terashita K, Chuma M, Hatanaka Y, Hatanaka K, Mitsuhashi T, Yokoo H, Ohmura T, Ishizu H, Muraoka S, Nagasaka A, Tsuji T, Yamamoto Y, Kurauchi N, Shimoyama N, Toyoda H, Kumada T, Kaneoka Y, Maeda A, Ogawa K, Natsuizaka M, Kamachi H, Kakisaka T, Kamiyama T, Taketomi A, Matsuno Y, Sakamoto N. ZEB1 expression is associated with prognosis of intrahepatic cholangiocarcinoma. J Clin Pathol. 2016; 69(7): 593-599.
Kawakubo K, Ohnishi S, Hatanaka Y, Hatanaka KC, Hosono H, Kubota Y, Kamiya M, Kuwatani M, Kawakami H, Urano Y, Sakamoto N. Feasibility of Using an Enzymatically Activatable Fluorescence Probe for the Rapid Evaluation of Pancreatic Tissue Obtained Using Endoscopic Ultrasound-Guided Fine Needle Aspiration: a Pilot Study. Mol Imaging Biol. 2016; 18(3): 463-471.
Naka T, Hatanaka Y, Marukawa M, Okada H, Hatanaka KC, Sakakibara-Konishi J, Oizumi S, Hida Y, Kaga K, Mitsuhashi T, Matsuno Y. Comparative genetic analysis of a rare synchronous collision tumor composed of malignant pleural mesothelioma and primary pulmonary adenocarcinoma. Diagn Pathol. 2016; 11: 38.
Sato D, Tsuchikawa T, Mitsuhashi T, Hatanaka Y, Marukawa K, Morooka A, Nakamura T, Shichinohe T, Matsuno Y, Hirano S. Stromal palladin expression is an independent prognostic factor in pancreatic ductal adenocarcinoma. Plos One. 2016; 11(3): e0152523.
Nakamura A, Mitsuhashi T, Takano Y, Miyoshi H, Kameda H, Nomoto H, Nagai S, Hatanaka Y, Shimizu C, Terauchi Y, Atsumi T. Usefulness of the octreotide test in japanese patients for predicting the presence/absence of somatostatin receptor 2 expression in insulinomas. Endocr J. 2016; 63(2): 135-142.
Oguro S, Ino Y, Shimada K, Hatanaka Y, Matsuno Y, Esaki M, Nara S, Kishi Y, Kosuge T, Hiraoka N. Clinical significance of tumor-infiltrating immune cells focusing on btla and cbl-b in patients with gallbladder cancer. Cancer Sci. 2015; 106(12): 1750-1760.
Yoshioka T, Hosoda M, Yamamoto M, Taguchi K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H. Prognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer. Breast Cancer. 2015; 22(2): 185-191.
Sato F, Kubota Y, Natsuizaka M, Maehara O, Hatanaka Y, Marukawa K, Terashita K, Suda G, Ohnishi S, Shimizu Y, Komatsu Y, Ohashi S, Kagawa S, Kinugasa H, Whelan KA, Nakagawa H, Sakamoto N. EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition. Cancer Biol Ther. 2015; 16(6): 933-940.
Fujita H, Hatanaka Y, Sutoh Y, Suzuki Y, Oba K, Hatanaka KC, Mitsuhashi T, Otsuka N, Fugo K, Kasahara M, Matsuno Y. Immunohistochemical validation and expression profiling of NKG2D ligands in a wide spectrum of human epithelial neoplasms. J Histochem Cytochem. 2015; 63(3): 217-227.
Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N. CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing. J Gastroenterol. 2015; 50(2): 203-210.
Mizukami T, Kamachi H, Mitsuhashi T, Tsuruga Y, Hatanaka Y, Kamiyama T, Matsuno Y, Taketomi A. Immunohistochemical analysis of cancer stem cell markers in pancreatic adenocarcinoma patients after neoadjuvant chemoradiotherapy. BMC Cancer. 2014; 14: 687.
Nitta T, Mitsuhashi T, Hatanaka Y, Miyamoto M, Oba K, Tsuchikawa T, Suzuki Y, Hatanaka KC, Hirano S, Matsuno Y. Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohisto-chemical study using a tissue microarray. Br J Cancer. 2014; 111: 1363-1372.
Hosoda M, Yamamoto M, Nakano K, Hatanaka KC, Takakuwa E, Hatanaka Y, Matsuno Y, Yamashita H. Differential expression of progesterone receptor, FOXA1, GATA3, and p53 between pre- and postmenopausal women with estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2014; 144(2): 249-261.
Sato H, Hatanaka KC, Hatanaka Y, Hatakeyama H, Hashimoto A, Matsuno Y, Fukuda S, Sabe H. High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients. Cell Commun Signal. 2014; 12: 17.
Soma S, Tsuta K, Takano T, Hatanaka Y, Yoshida A, Suzuki K, Asamura H, Tsuda H. Intratumoral distribution of egfr- amplified and EGFR-mutated cells in pulmonary adenocarcinoma. Pathol Res Pract. 2014; 210: 155-160.
Hayase E, Fujimoto K, Mitsuhashi T, Hatanaka Y, Yoshida M, Takemura R, Iwasaki J, Shiratori S, Sugita J, Kondo T, Tanaka J, Imamura M, Matsuno Y, Teshima T. Epstein-barr virus-associated smooth muscle tumors after bone marrow transplantation. Transplantation. 2014; 97(1): e1-e5.
Yamamoto M, Hosoda M, Nakano K, Jia S, Hatanaka KC, Takakuwa F, Hatanaka Y, Matsuno Y, Yamashita H. p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors. Cancer Sci. 2014; 105(1): 81-88.
海外学術集会での成果報告
Asano H, Matsuoka R, Hatanaka KC, Endo D, Nozaki A, Ihira K, Mitamura T, Kato T, Konno Y, Matsuno Y, Hatanaka Y, Watari H. Low expression of gamma-glutamyl transpeptidase 1 is an independent poor prognostic factor in ovarian clear cell carcinoma, in relation to up-regulation of immune suppressive genes and EMT-related genes. 2020 American Society of Clinical Oncology (ASCO) Annual Meeting, WEB, 2020 May 29–June 2.
Motoi N, Hatanaka Y, Hamakawa S, Kawahara A, Nagatomo T, Kuwata T, Oda Y, Okamoto A, Maeda I, Sato Y, Morii E. Clinical genomic test on cytology: Current status and future perspective in Japan (JSCC Working Group on cytological roles in genome medicine era). 20th International Congress of Cytology, Sydney, Australia, 2019 May 5-10(May 5).
Asano H, Matsuoka R, Hatanaka KC, Hatanaka Y, Kato T, Mitamura T, Konno Y, Akita H, Matsuno Y, Watari H. Correlation between the expression of glutathione metabolism-related genes and prognosis in ovarian clear cell carcinoma. AACR Annual Meeting 2019, Atranta, GA, USA, 2019 Mar 29-Apr 3 (Apr 2).
Kinoshita I, Kano S, Shimizu Y, Kiyota N, Tada Y, Ijichi K, Yamazaki T, Homma A, Ito YM, Nishimoto N, Ono K, Kobayashi K, Isoe T, Hatanaka Y, Tsuda H, Morinaga S, Matsuno Y, Dosaka-Akita H. Phase II study of trastuzumab and docetaxel therapy in patients with HER2-positive recurrent and/or metastatic salivary gland carcinoma. AACR Annual Meeting 2019, Atranta, GA, USA, 2019 Mar 29-Apr 3 (Apr 2).
Sakiyama S, Ohira H, Oda Y, Nakaya T, Watanabe T, Sakakibara J, Hatanaka KC, Hatanaka Y, Takakuwa E,Nishimura M, Tsujino I. Chronic thromboembolic pulmonary hypertension and Klippel-Trenaunay syndrome – a case report with genomic and histological considerations. European Respiratory Society International Congress 2018, Paris, France, 2018 Sep 15-19.
Takahashi H, Shinagawa N, Hatanaka Y, Kunisaki M, Furuta M, Takashima Y, Shouji T, Kitai H, Kikuchi H, Mizugaki H, Asahina H, Kikuchi E, Kikuchi J, Sakakibara J, Matsuno Y, Nishimura M. Retrospective analysis of tumor programmed death-ligand 1 expression in transbronchial biopsy samples. European Respiratory Society International Congress 2018, Paris, France, 2018 Sep 15-19(Sep 17).
Ihira K, Asano H, Hatanaka KC, Hatanaka Y, Okumura A, Nange A, Amano T, Mitamura T, Kato T, Konno Y, Endo D, Nozaki A, Matsuno Y, Watari H. Analysis of clinically actionable gene alterations in ovarian clear cell carcinoma. 17th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2018), Kyoto, Japan, 2018 Sep 14-16(Sep 15).
Bando H, Tsukada Y, Inamori K, Fukuoka S, Sasaki T, Nishizawa Y, Wakabayashi M, Kojima M, Togashi Y, Yuki S, Komatsu Y, Homma S, Hatanaka Y, Matsuno Y, Uemura M, Kato T, Sato A, Nishikawa H, Ito M, Yoshino T. Multicenter Phase Ib/II Study of Nivolumab Monotherapy and Subsequent Radical Surgery Following Preoperative Chemoradiotherapy (CRT) with Capecitabine in Patients with Locally Advanced Rectal Cancer (LARC). ESMO World Congress on Gastrointestinal Cancer 2018, Barcelona, Spain, 2018 Jun 20-23 (Jun 20).
Shimizu A, Hatanaka K, Hatanaka Y, Naruchi K, Sato M, Kase H, Mitsuhashi T, Yamashita H, Matsuno Y. Cancer-associated MUC1 epitope-recognizing antibody as a novel immunohistochemical marker for breast carcinoma. AACR Annual Meeting 2018, Chicago, Illinois, USA, 2018 Apr 14-18 (Apr 17).
Takashima Y, Sakakibara-Konishi J, Hatanaka Y, Hatanaka KC, Ohhara Y, Oizumi S, Hida Y, Kaga K, Kinoshita I, Dosaka-Akita H, Matsuno Y, Nishimura M. Clinicopathological features and immune microenvironment of non-small cell lung cancer with primary resistance to epidermal growth factor receptor-tyrosine kinase inhibitors. AACR Annual Meeting 2018, Chicago, Illinois, USA, 2018 Apr 14-18 (Apr 17).
Morimoto H, Maishi N, Hida Y, Nishihara H, Hatanaka Y, Matsuno Y, Nakamura T, Hirano S, Hida K. Biglycan, tumor endothelial secreting proteoglycan, as possible biomarker for lung cancer. AACR Annual Meeting 2018, Chicago, IL, USA, 2018 Apr 14-18 (Apr 16).
Asano H, Hatanaka Y, Hatanaka KC, Okumura A, Amano T, Mitamura T, Kato T, Konno Y, Endo D, Ihira K, Nozaki A, Matsuno Y, Watari H, Sakuragi N. Molecular analysis of clinically actionable gene alterations in clear cell carcinoma of the ovary using next-generation sequencing and immunohistochemical CNV analysis. AACR Annual Meeting 2018, Chicago, IL, USA, 2018 Apr 14-18 (Apr 16).
Tsukada Y, Bando H, Inamori K, Fukuoka S, Sasaki T, Nishizawa Y, Kotani D, Kojima M, Togashi Y, Nakamura N, Akimoto T, Komatsu Y, Yuki S, Homma S, Hatanaka Y, Matsuno Y, Sato A, Nishikawa H, Ito M, Yoshino T. Multicenter Phase 1b/2 Study of Nivolumab Monotherapy and Subsequent Radical Surgery after Preoperative Chemoradiotherapy with Capecitabine in Patients with Locally Advanced Rectal Cancer (EPOC1504). 2018 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 2018 Jan 18-20.
Ishida N, Hatanaka Y, Baba M, Hagio K, Okada H, Hatanaka KC, Matsuno Y, Yamashita H. PIK3CA mutation, reduced AKT serine 473 phosphorylation, and increased ERα serine 167 phosphorylation are positive prognostic indicators in postmenopausal estrogen receptor-positive, HER2-negative early breast cancer. San Antonio Breast Cancer Symposium 2017, San Antonio, TX, USA, 2017 Dec 5-9 (Dec 8).
Ohhara Y, Kinoshita I, Tomaru U, Hatanaka K, Hatanaka Y, Honma R, Takeuchi S, Shimizu Y, Kaga K, Matsuno Y, Dosaka-Akita H. Clinicopathological features of programmed cell death ligand 1 (PDL1) expression in resected non-small cell lung cancers. AACR Annual Meeting 2017, Washington, DC, USA, 2017 Apr 1-5 (Apr 3).
Marukawa K, Mitsuhashi T, Hatanaka Y, Morooka A, Sato D, Nitta T, Nakamura T, Hirano S, Matsuno Y. Clinicopathological significance of MUC13 expression in pancreatic ductal adenocarcinoma (PDAC); the positive prognostic marker and possible candidate for molecular targeted therapy. 2016 Annual Meeting, United States and Canadian Academy of Pathology, Washington State Convention Center, MA, USA, 2016 Mar.
Aiyama T, Orimo T, Yokoo H, Ohata T, Hatanaka K, Hatanaka Y, Matsuno Y, Kamiyama T, Taketomi A, APC-binding protein EB1 as an important predictive factor for the prognosis and recurrence in hepatocellular carcinoma. The Liver Meeting 2015 American Association for the Study of Liver Diseases, CA, USA, 2015 Nov.
Kawakubo K, Ohnishi S, Urano Y, Hatanaka Y, Hatanaka KC, Kawakami H, Kuwatani M, Kawahata S, Abe Y, Kubota Y, Kubo K, Sakamoto N. A novel technique for the detection of endoscopic ultrasound-guided fine needle pancreatic tissue acquisition by an enzymatically rapid-activatable fluorescent probe. Digestive Disease Week 2015 and the 116th annual meeting of the American Gastroenterological Association, Washington, D.C., USA, 2015 May.
Sato D, Mitsuhashi T, Tsuchikawa T, Hatanaka Y, Nakamura T, Hirano S, Matsuno Y. Stromal palladin expression is an independent prognostic factor of pancreatic ductal adenocarcinoma (PDAC). United States and Canadian Academy of Pathology (USCAP) 104th Annual Meeting, Boston, MA, USA, 2015 May 21-27.
Naka T, Hatanaka Y, Kanno H, Hatanaka KC, Mitsuhashi T, Matsuno Y. PHGDH and TRIM29 as novel diagnostic markers for malignant pleural mesothelioma: An exploring approach from FFPE tissue-based gene expression profiling of a synchronous thoracic tumor. United States and Canadian Academy of Pathology (USCAP) 104th Annual Meeting, Boston, MA, USA, 2015 May 21-27.
Hatanaka KC, Hatanaka Y, Fujii K, Kobayashi H, Kanno H, Nishihara H, Mitsuhashi T, Tanaka S, Matsuno Y. Predictive value of MGMT promoter and LINE-1 methylation status in primary central nervous system diffuse large B-cell lymphoma treated with high-dose MTX and radiotherapy. United States and Canadian Academy of Pathology (USCAP) 104th Annual Meeting, Boston, MA, USA, 2015 May 21-27.
Oguro S, Ino Y, Shimada S, Hatanaka Y, Matsuno Y, Kosuge T, Hiraoka N. Clinical significance of tumor-infiltrating immune cells focusing on BTLA and Cbl-b in patients with gallbladder cancer. American Association for Cancer Research: Tumor immunology and immunotherapy, Orlando, FL, USA, 2014 Dec 1-4.
Natsuizaka M, Kaimila B, Kubota Y, Hatanaka Y, Marukawa K, Terashita K, Sato F, Ohnishi S, Suda G, Ohashi S, Kagawa S, Whelan K, Rustgi AK, Nakagawa H, Sakamoto N. EGFR inhibitors eliminate esophageal cancer stem cells by suppressing epithelial-mesenchymal transition. Digestive Disease Week 2014 and the 115th annual meeting of the American Gastroenterological Association, Chicago, IL, USA, 2014 May 3-6.
Kubota Y, Kawakami H, Natsuizaka M, Kawakubo K, Marukawa K, Kudo T, Abe Y, Kubo K, Kuwatani M, Hatanaka Y, Mitsuhashi T, Matsuno Y, Sakamoto N. CTNNB1 Mutational Analysis of Solid-Pseudopapillary Neoplasms of the Pancreas Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Next-Generation Deep Sequencing. Digestive Disease Week 2014 and the 115th annual meeting of the American Gastroenterological Association, Chicago, IL, USA, 2014 May 3-6.